University of Wisconsin-Madison

Connie S. Chamberlain

Connie_Chamberlain-_UW_Madison.jpg

Title:

Contact Information: 

Department Affiliation:

Orthopedics & Rehabilitation

Education Background: 

B.S. Animal Science, University of Illinois at Champaign-Urbana
M.S. Reproductive Physiology, Oklahoma State University
M.S. & Ph.D. Materials Science, University of Wisconsin-Madison

Research Description:

We are interested in discovering a method to reduce scar and/or stimulate regeneration. We are currently studying numerous branches of biology including digit tip regeneration, the role of mesenchymal stem cells, modulation of the immune cells, localized delivery of proteins to the wound, and application of platelet rich plasma

Publications: 

  1. C. Chamberlain, E. Leiferman, S. Brickson, G. Baer, W.L. Murphy, R. Vanderby. Interleukin-1 Receptor Antagonist Modulates Inflammation and Scarring after Ligament Injury.Connective Tissue Research, 2014;3:177-86.
  2. C.S. Chamberlain, J.S. Lee, E.M. Leiferman, N.X. Maassen, G.S. Baer, R. Vanderby, W.L. Murphy. Effects of BMP-12 releasing sutures on Achilles tendon healing. Tissue Engineering A, 2015; 21: 916-27.
  3. Saether EE, Chamberlain CS, Leiferman EM, Kondratko-Mittnacht JR, Li WJ, Brickson SL, Vanderby R. Enhanced Medial Collateral Ligament Healing Using Mesenchymal Stem Cells: Dosage Effects on Cellular Response and Cytokine Profile. Stem Cell Rev. 2013 Oct 31. [Epub ahead of print] PubMed PMID: 24174129.
  4. Chamberlain CS, Leiferman EM, Frisch KE, Brickson SL, Murphy WL, Baer GS, Vanderby R. Interleukin expression after injury and the effects of interleukin-1 receptor antagonist. PLoS One. 2013 Aug 1;8(8):e71631. doi: 10.1371/journal.pone.0071631. Print 2013. PubMed PMID: 23936523; PubMed Central PMCID: PMC3731283.
  5. Chamberlain CS, Duenwald-Kuehl SE, Okotie G, Brounts SH, Baer GS, Vanderby R. Temporal healing in rat achilles tendon: ultrasound correlations. Ann Biomed Eng. 2013 Mar;41(3):477-87. doi: 10.1007/s10439-012-0689-y. Epub 2012 Nov 13. PubMed PMID: 23149902; PubMed Central PMCID: PMC3600106.
  6. Franklin-Ford T, Shah N, Leiferman E, Chamberlain CS, Raval A, Vanderby R, Murphy WL. Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles. Macromol Biosci. 2012 Dec;12(12):1615-21. doi: 10.1002/mabi.201100489. Epub 2012 Nov 1. PubMed PMID: 23124987; PubMed Central PMCID: PMC3746814.
  7. Chamberlain CS, Crowley EM, Kobayashi H, Eliceiri KW, Vanderby R. Quantification of collagen organization and extracellular matrix factors within the healing ligament. Microsc Microanal. 2011 Oct;17(5):779-87. doi: 10.1017/S1431927611011925. Epub 2011 Sep 13. PubMed PMID: 21910939; PubMed Central PMCID: PMC3263369.
  8. Chamberlain CS, Brounts SH, Sterken DG, Rolnick KI, Baer GS, Vanderby R. Gene profiling of the rat medial collateral ligament during early healing using microarray analysis. J Appl Physiol (1985). 2011 Aug;111(2):552-65. doi: 10.1152/japplphysiol.00073.2011. Epub 2011 May 19. PubMed PMID: 21596919; PubMed Central PMCID: PMC3154688.
  9. Frisch KE, Duenwald-Kuehl SE, Kobayashi H, Chamberlain CS, Lakes RS, Vanderby R Jr. Quantification of collagen organization using fractal dimensions and Fourier transforms. Acta Histochem. 2012 Feb;114(2):140-4. doi: 10.1016/j.acthis.2011.03.010. Epub 2011 May 6. PubMed PMID: 21529898; PubMed Central PMCID: PMC3158952.
  10. Chamberlain CS, Leiferman EM, Frisch KE, Wang S, Yang X, Brickson SL, Vanderby R. The influence of interleukin-4 on ligament healing. Wound Repair Regen. 2011 May-Jun;19(3):426-35. doi: 10.1111/j.1524-475X.2011.00682.x. Epub 2011 Apr 21. PubMed PMID: 21518087; PubMed Central PMCID: PMC3147289.
  11. Chamberlain CS, Leiferman EM, Frisch KE, Wang S, Yang X, van Rooijen N, Baer GS, Brickson SL, Vanderby R. The influence of macrophage depletion on ligament healing. Connect Tissue Res. 2011 Jun;52(3):203-11. doi: 10.3109/03008207.2010.511355. Epub 2010 Nov 30. PubMed PMID: 21117894; PubMed Central PMCID: PMC3110150.
  12. Chamberlain CS, Crowley E, Vanderby R. The spatio-temporal dynamics of ligament healing. Wound Repair Regen. 2009 Mar-Apr;17(2):206-15. doi: 10.1111/j.1524-475X.2009.00465.x. Erratum in: Wound Repair Regen. 2009 May-Jun;17(3):459-60. PubMed PMID: 19320889; PubMed Central PMCID: PMC3214965.
  13. Aktas E, Chamberlain CS, Saether EE, Duenwald-Kuehl SE, Kondratko-Mittnacht J, Stitgen M, Lee JS, Clements AE, Murphy WL, Vanderby R. Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect 2016, journal of orthopedic research DOI: 10.1002/jor.23258

Awards & Honors:

Patents and Grants:

  • Principle Investigator, AO Foundation Grant, “Osteoblast Cell Fate and Cell Signaling During Bone Regeneration”, University of Wisconsin-Madison (2 years).