University of Wisconsin-Madison

Human pluripotent stem cells (hPSCs) adhere to synthetic extracellular matrices (ECM) composed of poly(ethylene glycol) (PEG). Immunofluorescence image of hPSCs cultured on PEG hydrogel substrate after 3 days [F-actin (phalloidin, red), vinculin (green), nuclei (DAPI,blue)]

Image provided by Ngoc Nhi Le.

Tech Transfer

The Murphy Group is actively pursuing technology transfer efforts in conjunction with the Wisconsin Alumni Research Foundation (WARF). For details on these efforts please contact Dr. Murphy (wlmurphy@wisc.edu) or Jeanine Burmania (jeanine@warf.org) at WARF.

Patents

IP-44.    L. Jongpaiboonkit, W.L. Murphy. Osteostimulatory mineral coatings that reduce bacterial adhesion. Patent Application filed, 2017. 

IP-43.    A.S. Khalil, X. Yu, W.L. Murphy. Mineral-coated microparticles for gene delivery in chronic wound therapy. Patent Application filed, 2017. 

IP-42.    A.S. Khalil, X. Yu, W.L. Murphy. Mineral-coated microparticles for the co-delivery of anti-inflammatory molecules with nucleic acids to improve gene delivery outcomes. Patent Application filed, 2017. 

IP-41.    A. Clements, C. Chamberlain, R. Vanderby Jr., W.L. Murphy. Mineral coated microparticles for sustained delivery of biologically active molecules. Patent Application filed, 2017.

IP-40.    A.S. Khalil, C. Lebakken, W.L. Murphy. Visible light polymerization of PEG hydrogels. Patent Application filed, 2017. 

IP-39.    W.L. Murphy, G. Fontana. Functionalization of plant tissues for human cell expansion. Patent Application filed, 2017. 

IP-38.    J. Gershlak, G. Gaudette, P. Weathers, T. Dominko, M. Rolle, S. Hernandez, W.L. Murphy, C. Cramer, Fabricio Medina-Bolivar. Decellularization of plant tissues. Patent Application filed, 2016. 

IP-37.    D.G. Belair, N.N. Le, A. Kellner, W.L. Murphy. TGF-β1-binding peptides and hydrogel microspheres containing the peptides for growth factor regulation in blood products. Patent Application filed, 2016. 

IP-36.    D.G. Belair, N.N. Le, W.L. Murphy. Hydrogel spheres containing peptide ligands for growth factor regulation. Patent Application filed, 2016. 

IP-35.    J. Lei, W.L. Murphy, J.S. Temenoff. Development of HEPpep and heparin coatings for MSC spheroid microtissue assembly. Patent Application filed, 2016. 

IP-34. A.S. Khalil, X. Yu, K. Saha, J. Carlson-Stevermer, B. Steyer, W.L. Murphy. Fluoride-doped inorganic coatings for controlled delivery of DNA, RNA, and protein-RNA hybrids. Patent Application, Filed 2015.

IP-33. L. Jongpaiboonkit, W.L. Murphy. Mineral-coated Scaffolds. Patent Application, Filed 2015.

IP-32. L. Jongpaiboonkit, W.L. Murphy. Coating scaffolds. Patent Application, Filed 2015.

IP-31.   N.N. Le, M. Parlato, J.A. Molenda, W.L. Murphy. Hydrogel arrays for cell expansion and differentiation. U.S. Patent Application, Filed 2015. 

IP-30.    W.L. Murphy, E. Nguyen, M. Schwartz, H. Ardalani, M. Zanotelli, M. Parlato, D. Belair, W. Daly, N.N. Le. Synthetic hydrogel compositions that promote endothelial cell tubulogenesis. U.S. Patent Application Filed, 2015.

IP-29.   S.K. Schmitt,  P. Gopalan, W.L. Murphy. Azlactone based thermally crosslinkable polymer coating for controlling cell behavior. U.S. Patent Application, Filed 2015. 

IP-28.    L. Guo, X. Yu, W.L. Murphy, C. Kent. Perivascular delivery system and method. U.S. Patent Application, Filed 2014. 

IP-27.    Z. Hou, M.P. Schwartz, W.L. Murphy, J.A. Thomson. Human pluripotent stem cell-based models for predictive developmental neural toxicity. U.S. Patent Application, Filed 2014. 

IP-26.    A.W. Xie, W.L. Murphy. Chemically labile peptide-presenting surfaces for cellular self-assembly. U.S. Patent Application, Continuation in part, Filed 2014. internet_link.jpg

IP-25.    L. Jongpaiboonkit, W.L. Murphy. Custom coatings on orthopedic implants. U.S. Patent Application Filed, 2014.

IP-24.    N.N. Le, W.L. Murphy. Photopolymerization patterning for formation of covalently-immobilized hydrogel arrays in multi-well plates. U.S. Patent Application Filed, 2014. 

IP-23. N.N. Le, S. Zorn, M.P. Schwartz, E.H. Nguyen, W.L. Murphy. Novel method for forming hydrogel arrays using surfaces with differential wettability. U.S. Patent Application Filed, 2014.

IP-22.    W.L. Murphy, J.S. Lee, J.S. Lee, M. Markel, B. Graf. Methods of decorating hydroxyapatite biomaterials with modular, biologically active molecules. U.S. Patent Application Filed, 2013. internet_link.jpg

IP-21.    W.L. Murphy, S. Choi, X. Yu. Enhanced throughput mineral coatings for optimization of stem cell behavior. Patent Application filed, 2013. internet_link.jpg

IP-20.    W.L. Murphy, S. Lan Levengood, J.T. Koepsel, S. Zorn, T. Keenan. Substrates for generation of controlled human pluripotent stem cell colony size. Patent Application filed, 2012. internet_link.jpg

IP-19.    W.L. Murphy, S. Lan Levengood, S. Brounts. Modular, bioactive peptide binds to bone and improves bone graft osteoinductivity. Patent Application filed, 2012.

IP-18.    S.J. Hollister, S.J. Feinberg, W.L. Murphy, L. Jongpaiboonkit, J.R. Adox, F. Migneco. Modular tissue scaffolds. Patent Application Filed, 2012. internet_link.jpg

IP-17.    W.L. Murphy, J.T. Koepsel. Chemically-defined arrays for screening cell-substrate interactions. Patent Application Filed, 2012. internet_link.jpg

IP-16.    W.L. Murphy, R. Vanderby, G. Baer, B. Graf, J.S. Lee, C. Chamberlain. Medical device coatings that bind and deliver blood components. Patent Application Filed, 2011.

IP-15.    C.Y. Lin, F. LaMarca, W.L. Murphy, S.J. Hollister. Degradable cage coated with mineral layers for spinal interbody fusion. Continuation in Part Application Filed, 2011. internet_link.jpg

IP-14.    J.S. Lee, D. Suarez-Gonzalez, M. Markel, Y. Lu, B. Graf, W.L. Murphy. Tissue regeneration system. U.S. Patent Application Filed (serial #12/796743), 2010. internet_link.jpg

IP-13.  J.S. Lee, M. Markel, B. Graf, G. Baer, Y. Lu, W.L. Murphy, Biologically active sutures for regenerative medicine. U.S. Patent Application Filed (serial #12/507635), 2009. internet_link.jpg

IP-12.  G. Hudalla, W.L. Murphy. Proteoglycan-binding peptides that modulate stem cell behavior. Patent Application Filed (serial #61/326945), 2009. internet_link.jpg

IP-11.  W.L. Murphy, J.S. Lee, J.S. Lee, M. Markel, B. Graf. Decorating hydroxyapatite biomaterials with modular, biologically active molecules. U.S. Patent Application Filed (serial #12/628666), 2009. internet_link.jpg

IP-10.  L. Jongpaiboonkit, W.L. Murphy. Mineral-coated microspheres. U.S. Patent Application Filed, 2008. internet_link.jpg

IP-9.  W.L. Murphy, J.S. Lee, M. Markel, B. Graf. Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery. U.S. Patent Application Filed (serial #12/145672), 2008. internet_link.jpg

IP-8.  C.Y. Lin, F. LaMarca, W.L. Murphy, S.J. Hollister. Degradable cage coated with mineral layers for spinal interbody fusion. U.S. Patent Application Filed (serial #11/927322), 2006. internet_link.jpg

IP-7.  C.Y. Lin, F. LaMarca, S. Feinberg, W.L. Murphy, J. Adox, S.J. Hollister. Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration. U.S. Patent US 8,275,594 B2. internet_link.jpg

IP-6.  W.L. Murphy. Multilayer tissue regeneration system. U.S. Patent Application 20080095817 (serial #11/583231), 2006. internet_link.jpg

IP-5.  W.L. Murphy, S. Choi. Method and system for delivery of a nucleic acid into a target cell. U.S. Patent Application 20070092906 (serial #11/583223), 2006. internet_link.jpg

IP-4.  W.L. Murphy, G. Hudalla. Spatial control of signal transduction. U.S. Patent Application 60675225 (serial #11/412450), 2006. internet_link.jpg

IP-3.  W.L. Murphy, R.G. Dennis, D.J. Mooney. Tissue engineering scaffolds. U.S. Patent 7,575,759. internet_link.jpg

IP-2.  W.L. Murphy, M.C. Peters, D.J. Mooney. Mineralization and biological modification of biomaterial surfaces. U.S. Patent 6,767,928. internet_link.jpg

IP-1.  W.L. Murphy, M.T. Dearing, G.C. Spalding, D.J. Mooney, D.H. Kohn. Mineral and cellular patterning on biomaterial surfaces. U.S. Patent 6,541,022. internet_link.jpg