University of Wisconsin-Madison

William Daly



Contact Information: 

Human Models for Analysis of Pathway's (H-MAP's) Core Director/Scientist

Department Affiliation:

 Department of Orthopedics and Rehabilitation 

Education Background:

Ph.D. Biomedical Engineering, National University of Ireland, Galway
B.S. Biomedical Engineering, National University of Ireland, Galway

Research Description:

Understanding the development of vascular and neural networks/tissues in controlled micro-environments ex vivo and the establishment of new treatment modalities using human induced pluripotent stem cells.


  1.  Daly WT, Yao L, Zeugolis DI, Windebank AJ, Pandit AS. A biomaterials approach to  peripheral nerve regeneration: Bridging the peripheral nerve gap and enhancing functional recovery. J R Soc Interface. 2012;9(67):202-21. internet_link.jpg
  2. Yao L., Yao S., Daly WT. Hendry W., Windebank AJ., and Pandit AS. Non-viral gene therapy for spinal cord regeneration. Drug Discov Today 2012; 17(18):998-1005 internet_link.jpg      
  3. Daly WT, Yao L, Abu-Rub MT, O'Connell C, Zeugolis DI, Windebank AJ, Pandit AS. The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair. Biomaterials. 2012;33(28):6660-71.internet_link.jpg
  4. Yao L, Daly WT, Newland B, Yao S, Wang W, Chen BK, Madigan N, Windebank A,Pandit A. Improved axonal regeneration of transected spinal cord mediated by multichannelcollagen conduits functionalized with neurotrophin-3 gene. Gene Ther. 2013;20(12):1149-57.internet_link.jpg
  5. Daly WT, Knight AM, Wang H, De Boer R, Giusti G, Dadsetan M, Spinner RJ,Yaszemski MJ, Windebank AJ. Comparison and characterization of multiple biomaterial conduits for peripheral nerve repair. Biomaterials. 2013;34(34):8630-9. internet_link.jpg       
  6.  Schwartz M., Hou Z., Propson N., Zhang J., Engstrom C., Costa V.S., Jiang P., Nguyen B., Bolin J., Daly W., Wang  Y., Stewart R., Page D., Murphy W., Thomson J. Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. PNAS. 112(40):12516-12521 
  7. Nguyen E.*, Daly W*., , Le N., Farnoodian M., Belair D., Schwartz M., Lebakken C., Ananiev G., Saghiri A, Knudsen T., Sheibani N., Murphy W. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nature Biomedical Engineering. 1. 00906
  8. Daly W, Niemier R. , Dillon S. T. , Wang H., Mirsky R. , Jessen  K., Windebank A., Pandit A. Spatial Differences in Cellular and Molecular Responses as a Function of the Material Used in Conduit-Mediated Repair and Autograft Treatment of Peripheral Nerve Injuries Adv. Funct. Mater. 2017, 1702170.



Awards & Honors: 


  • Principal Investigator, ICTR,  “Developing a Human Pluripotent Stem Cell-Derived 3D Vascularized Cerebral Organoid Culture System” 09/2017-09/2018 
  • Principal Investigator, NIH/NCATS, "Modelling Rett Syndrome in Vascularized Neural Assemblies" (UH3TR000506-05S2) NIH/NCATS


  • Best podium presentation (European Society of Biomaterials, 2012)
  • Research on front page of Journal of the Royal Society Interface (2012)
  • Short term travel fellowship award (Science Foundation Ireland, 2011)
  • Best podium presentation (Neuroscience Ireland, 2010)