Jae Sung Lee

Position title: Scientist III

Email: lee283@wisc.edu

Department Affiliation: 
Department of Orthopedics and Rehabilitation
B.S. Chemical Engineering, Seoul National University, South Korea
M.S. Chemical Engineering, Korea Advanced Institute of Science and Technology (KAIST), South Korea
Ph.D. Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Research Description:

Therapeutic use of platelet-rich plasma and bone marrow clots for musculoskeletal repair and regeneration


  1. D. Hellenbrand, C. Haldeman, J.S. Lee, A. Gableman, E. Dai, S. Ortmann, J. Gotchy, K. Miller, A. Doucas, N. Nowak, W.L. Murphy, A. Hanna. Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles. Neural Regeneration Research, 2021; 16: 871-877
  2. G. Fontana, H.L. Martin, J.S. Lee, K. Schill, P. Hematti, W.L. Murphy. Mineral-coated microparticles enhance mRNA-based transfection of human bone marrow cells. Molecular Therapy – Nucleic Acids, 2019; 18 :455-464
  3. S.W. Bae, J.S. Lee, W.L. Murphy. Dynamic, bioresponsive hydrogels via changes in DNA aptamer conformation. Macromolecular Bioscience, 2019; 19: e1800353
  4. G. Fontana, J. Gershlak, M. Adamski, J.S. Lee, S. Matsumoto, H.D. Le, B. Binder, J. Wirth, G. Gaudette, W.L. Murphy. Biofunctionalized plants as diverse biomaterials for human cell culture. Advanced Healthcare Materials, 2017; 6: 8
  5. X. Yu, J.S. Lee, A.J. Wagoner-Johnson, W.L. Murphy. Mineral binding peptides with enhanced binding stability in serum. Biomaterials Science, 2017, 5, 663–668
  6. E. Aktas, C. S. Chamberlain, E. E. Saether, S. E. Duenwald-Kuehl, J. Kondratko-Mittnacht, M. Stitgen, J. S. Lee, A. E. Clements, W. L. Murphy, R. Vanderby, “Immune Modulation with Primed Mesenchymal Stem Cells Delivered via Biodegradable Scaffold to Repair an Achilles Tendon Segmental Defect”, Journal of Orthopedic Research 2017; 35: 269-280.
  7.  S. J. Polak, J. S. Lee, W. L. Murphy, S. Tadier, L. Gremillard, I. V. Lightcap, A. J. W. Johnson, “Microstructural Control of Modular Peptide Release from Microporous Biphasic Calcium Phosphate”, Materials Science and Engineering C, 72 268-277 2017.
  8.  A. S. Hanna, D. L. Thompson, D. J. Hellenbrand, J. S. Lee, C. J. Madura, M. G. Wesley, N. J. Dillon, T. Sharma, C. J. Enright, W. L. Murphy, “Sustained Release of Neurotrophin-3 via Calcium Phosphate-Coated Sutures Promotes Axonal Regeneration after Spinal Cord Injury”, Journal of Neuroscience Research 94 (7) 645-652 2016.
  9.  C. S. Chamberlain, J. S. Lee, E. M. Leiferman, N. X. Maassen, G. S. Baer, R. Vanderby, W. L. Murphy, “Effects of BMP-12-Releasing Sutures on Achilles Tendon Healing”, Tissue Engineering, Part A 21 (5-6) 916-927 2015.
  10. S. R. Caliari, E. A. Gonnerman, W. K. Grier, D. W. Weisgerber, J. M. Banks, A. J. Alsop, J. S. Lee, R. C. Bailey, B. A. C. Harley, “Collagen Scaffold Arrays for Combinatorial Screening of Biophysical and Biochemical Regulators of Cell Behavior”, Advanced Healthcare Materials 4 (1) 59-64 2015.
  11.  D. Suarez-Gonzalez, J. S. Lee, A. Diggs, Y. Lu, B. Nemke, M. D. Markel, S. J. Hollister, W. L. Murphy, “Controlled Multiple Growth Factor Delivery from Bone Tissue Engineering Scaffolds via Designed Affinity”, Tissue Engineering, Part A 20 (15-16) 2077-2087 2014.
  12.  J. S. Lee*, S. H. Brounts*, S. Weinberg, S. K. Lan Levengood, E. L. Smith, W. L. Murphy, “High Affinity Binding of an Engineered, Modular Peptide to Bone Tissue”, Molecular Pharmaceutics 10 (5) 2086-2090 2013. (* Equally contributed to this work)
  13.  J. S. Lee, W. L. Murphy, “Functionalizing Calcium Phosphate Biomaterials with Antibacterial Silver Particles”, Advanced Materials 25 (8) 1173-1179 2013.
  14. Y. Lu, J. S. Lee, B. Nemke, B. K. Graf, K. Royalty, R. Illgen, R. Vanderby, M. D. Markel, W. L. Murphy, “Coating with a Modular Bone Morphogenetic Peptide Promotes Healing of a Bone-Implant Gap in an Ovine Model”, PLoS One 7 (11) e50378 2012.
  15.  J. S. Lee*, D. Suarez-Gonzalez*, S. K. Lan Levengood, R. Vanderby, W. L. Murphy, “Mineral Coatings Modulate beta-TCP Stability and Enable Growth Factor Binding and Release”, Acta Biomaterialia 8 (3) 1117-1124 2012. (* Equally contributed to this work)
  16.  J. S. Lee, D. Suarez-Gonzalez, W. L. Murphy, “Mineral Coatings for Temporally Controlled Delivery of Multiple Proteins”, Advanced Materials 23 (37) 4279-4284 2011. (Featured on Frontispiece)
  17.  Y. Lu, J. S. Lee, B. Nemke, G. Baer, B. K. Graf, W. L. Murphy, M. D. Markel, “Histologic Evaluation of Suture Material Loaded with Basic Fibroblast Growth Factor (bFGF) on Acute Rotator Cuff Repair in Ovine Model”, Current Orthopaedic Practice 22 (5) 425-431 2011.
  18.  D. J. Gary, H. Lee, R. Sharma, J. S. Lee, Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park, B. S. Herbert, S. F. Konieczny, Y. Y. Won, “Influence of Nano-Carrier Architecture on In Vitro siRNA Delivery Performance and In Vivo Biodistribution: Polyplexes vs. Micelleplexes”, ACS Nano 5 (5) 3493-3505 2011.
  19.  J. S. Lee, A. J. W. Johnson, W. L. Murphy, “A Modular, Hydroxyapatite-Binding Version of Vascular Endothelial Growth Factor”, Advanced Materials 22 (48) 5494-5498 2010. (Featured on Inside Cover)
  20.  J. S. Lee, Y. Lu, G. S. Baer, M. D. Markel, W. L. Murphy, “Controllable Protein Delivery from Coated Surgical Sutures”, Journal of Materials Chemistry 20 (40) 8894-8903 2010.
  21.  J. S. Lee, J. S. Lee, W. L. Murphy, “Modular Peptide Promote Human Mesenchymal Stem Cell Differentiation on Biomaterial Surfaces”, Acta Biomaterialia 6 (1) 21-28 2010.
  22.  J. S. Lee, J. S. Lee, A. J. W. Johnson, W. L. Murphy, “Modular Peptide Growth Factors for Substrate-Mediated Stem Cell Differentiation”, Angewandte Chemie International Edition 48 (34) 6266-6269 2009.
  23.  J. S. Lee, S. J. Hwang, D. J. Kim, S. C. Kim, D. S. Lee, “Formation of Poly(ethylene glycol)-Poly(?-caprolactone) Nanoparticle via Nanoprecipitation”, Macromolecular Research 17 (2) 72-78 2009.
  24.  R. Sharma, J. S. Lee, R. C. Bettencourt, C. Xiao, S. F. Konieczny, Y. Y. Won, “Effects of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction Properties of the Polymer-DNA Complexes”, Biomacromolecules 9 (11) 3294-3307 2008.
  25.  J. S. Lee, H. K. Lee, S. C. Kim, “Intrinsic Viscosity and Unperturbed Dimension of Poly(dl-lactic acid) Solution”, Macromolecular Research, 16 (7) 631-636 2008.
  26.  D. Zhu, M. A. Haiderkker, J. S. Lee, Y. Y. Won, J. C. M. Lee, “Application of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Melts”, Macromolecules 40 (21) 7730-7732 2007.
  27.  W. S. Shim, J. S. Lee, D. S. Lee, “pH-Induced Micellization of Biodegradable Block Copolymers Containing Sulfamethazine”, Macromolecular Research 13 (4) 344-351 2005.
  28.  M. S. Kim, W. S. Shim, R. R. Pal, J. S. Lee, S. W. Kim, D. S. Lee, “pH-Induced Micellization of Sulfamethazine-coupled MPEG-PCLA Block Copolymer”, Macromolecular Research 13 (4) 352-355 2005.
  29. J. S. Lee, S. H. Kim, Y. J. Kim, T. Akaike, S. C. Kim, “Hepatocyte Adhesion on Poly[N-p-vinylbenzyl-4-O-beta-galactopyranosyl-D-glucoamide]-coated Poly(L-lactic acid) Surface”, Biomacromolecules 6 (4) 1906-1911 2005.
  30. J. S. Lee, H. K. Lee, S. C. Kim, “Thermodynamic Parameters in Poly(lactic acid) Solutions in Dialkyl Phthalate”, Polymer 45 (13) 4491-4498 2004.
  31.  J. S. Lee, H. K. Lee, J. Y. Kim, S. Hyon, S. C. Kim, “Thermally Induced Phase Separation in Poly(lactic acid)/Dialkyl Phthalate Systems”, Journal of Applied Polymer Science 88 (9) 2224-2232 2003.
  32.  K. J. Baik, J. Y. Kim, J. S. Lee, H. K. Lee, S. C. Kim, “Morphology of Membranes Formed from Polysulfone/Polyethersulfone/N-methyl-2-pyrrolidone/Water System by Immersion Precipitation”, Korea Polymer Journal 9 (5) 285-291 2001.


1. J. S. Lee, M. D. Markel, B. K. Graf, G. Baer, Y. Lu, W. L. Murphy, “Biologically Active Sutures for Regenerative Medicine”, Patent Application Filed (US 2011/0022085).
2 W. L. Murphy, J. S. Lee, M. D. Markel, B. K. Graf, “Decorating Hydroxyapatite Biomaterials with Modular, Biologically Active Molecules”, Issued (US 8420774).
3. W. L. Murphy, J. S. Lee, M. D. Markel, B. K. Graf, “Methods of Decorating Hydroxyapatite Biomaterials with Modular, Biologically Active Molecules”, Issued (US 8846860).
4. W. L. Murphy, M. D. Markel, B. K. Graf, Y. Lu, J. S. Lee, “Tissue Regeneration System”, Issued (US 8778869).
5. W. L. Murphy, G. A. Hudalla, J. T. Koepsel, J. S. Lee, S. Levengood, “Proteoglycan-Binding Peptides that Modulate Stem Cell Behavior”, Patent Application Filed (US 2011/0269231).
6. C. S. Chamberlain, J. S. Lee, B. K. Graf, G. S. Baer, R. Vanderby, W. L. Murphy, “Selection of Platelet Rich Plasma Components via Mineral Binding”, Patent Application Filed (US2014/0141047).
7. W. L. Murphy, S. K. Lan Levengood, S. H. Brounts, J. S. Lee, “Modular, Bioactive Peptides for Binding Native Bone and Improving Bone Graft Osteoinductivity”, Patent Application Filed (US2014/0235542).