University of Wisconsin-Madison


Confocal image of stem cell-derived endothelial cells invading a biomimetic PEG hydrogel matrix.

Image provided by David G. Belair.



B-2.       W.L. Murphy Ed. Handbook of Biomaterial Properties. Springer, 2016.

J-134.    D.G. Belair, M.P. Schwartz, T. Knudsen, W.L. Murphy. Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Acta Biomaterialia. In Revision.

J-133.    E. Aktas, C.S. Chamberlain, E.E. Saether, S.E. Duenwald-Kuehl, J. Kondratko-Mittnacht, M. Stitgen, J.S. Lee, A.E. Clements, W.L. Murphy, R. Vanderby. Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect. Journal of Orthopedic Research. Accepted

J-132.    D.G. Belair, M.J. Miller, S. Wang, S.R. Darjatmokon, N. Sheibani, W.L. Murphy. Differential regulation of angiogenesis using degradable VEGF-binding microspheres. Biomaterials 

J 131.    D.G. Belair, N.N.T. Le, W.L. Murphy. Regulating VEGF signaling in platelet concentrates via specific VEGF sequestering. Biomaterials Science.

J-130.    M.R. Zanotelli, H. Ardalani, J. Zhang, Z. Hou, E.H. Nguyen, S. Swanson, B.K. Nguyen, J. Bolin, L. Bischel, A.W. Xie, R. Stewart, D.J. Beebe, J.A. Thomson, M.P. Schwartz, W.L. Murphy. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomaterialia

J-129.    A. Hanna, D. Thompson, D. Hellenbrand, J.S. Lee, C. Madura, M. Wesley, N. Dillon, T. Sharma, C. Enright, W.L. Murphy. Sustained release of neurotrophin-3 via calcium phosphate coated sutures promotes axonal regeneration after spinal cord injury. Journal of Neuroscience Research

J-128.    P. Dang, N. Dwivedi, X. Yu, L. Phillips, C. Bowerman, W.L. Murphy, E. Alsberg. Guiding chondrogenesis and osteogenesis with mineral-coated hydroxyapatite and BMP-2 incorporated within high-density hMSC aggregates for bone regeneration. ACS Biomaterials Science and Engineering

J-127.    N.N.T. Le, S. Zorn, S.K. Schmitt, P. Gopalan, W.L. Murphy. Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Acta Biomaterialia 2016; 34: 93–103.

J-126.    Y. Wang, X. Yu, C. Baker, W.L. Murphy, T.C. McDevitt. Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates. Acta Biomaterialia, 2016; 29: 42–51

J-125.    P. Dang, L. Solorio, S. Herberg, N. Dwivedi, L. Phillips, C. Bowerman, X. Yu, W.L. Murphy, E. Alsberg. Controlled growth factor delivery from microparticles incorporated within hMSC aggregates for enhanced bone tissue engineering via endochondral ossification. Stem Cells Translational Medicine, 2016; 5: 206-217. 

J-124.    S.K. Schmitt, D. Trebatowski, J.D. Krutty, A.W. Xie, B. Rollins, W.L. Murphy, P. Gopalan. Peptide conjugation to a polymer coating via native chemical ligation of azlactones for cell culture. Biomacromolecules internet_link


B-1.    G.A. Hudalla and W.L. Murphy Eds.. Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials. Royal Society of Chemistry, 2015.

J-123.    N.N.T. Le, S. Zorn, S.K. Schmitt, P. Gopalan, W.L. Murphy. Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Acta Biomaterialia, Accepted

J-122.    S. Pellett, M.P. Schwartz, W.H. Tepp, R. Josephson, J.M. Scherf, C.L. Pier, J.A. Thomson, W.L. Murphy, Eric A. Johnson. Human induced pluripotent stem cell derived neuronal cells cultured on chemically-defined hydrogels for sensitive in vitro detection of botulinum neurotoxin. Scientific Reports, Accepted.

J-121.    M.P. Schwartz, Z. Hou, N.E. Propson, J. Zhang, V.S. Costa, P. Jiang, B.K. Nguyen, J. Bolin, C. Engstrom, W. Daly, Y. Wang, R. Stewart, C.D. Page, W.L. Murphy, J.A. Thomson. Human pluripotent stem cell-derived neural constructs for predictive neurotoxicity. Proceedings of the National Academy of Sciences, Accepted.

J-120.    L.D. Solorio, L.M. Phillips, A. McMillan, C.W. Cheng, P.N. Dang, J.E. Samorezov, X. Yu, W.L. Murphy, E. Alsberg. Spatially organized differentiation of mesenchymal stem cells within biphasic microparticle-incorporated high cell density osteochondral tissues. Advanced Healthcare Materials, Accepted.

J-119.    J.W. Checco, E.F. Lee, M. Evangelista, N.J. Sleebs, K. Rogers, A. Pettikiriarachchi, N.J. Kershaw, G.A. Eddinger, D.G. Belair, J.L. Wilson, C.H. Eller, R.T. Raines, W.L. Murphy, B.J. Smith, S.H. Gellman, W.D. Fairlie. α/β-Peptide foldamers targeting intracellular protein-protein interactions with activity in living cells. Journal of the American Chemical Society, 2015; 137: 11365-11375.

J-118.    S.K. Schmitt, A.W. Xie, R.M. Ghassemi, D.J. Trebatoski, W.L. Murphy, P. Gopalan. Polyethylene glycol coatings on plastic substrates for chemically defined stem cell culture. Advanced Healthcare Materials, Accepted.

J-117.    J.A. Martin, A.H. Biedrzycki, S.H. Brounts, W.L. Murphy, M.D. Markel, R.J. DeWall, K.S. Lee, D.G. Thelen. In vivo measures of shear wave speed as a predictor of tendon elasticity and strength. Ultrasound in Medicine and Biology, Accepted. 

J-116.    X. Yu, D. Suarez-Gonzalez, A.S. Khalil, W.L. Murphy. How does the pathophysiological context influence delivery of bone growth factors? Advanced Drug Delivery Reviews, Accepted. 

J-115.    D.G. Belair, J.A. Whisler, J. Valdez, J. Velazquez, J.A. Molenda, V. Vickerman, R. Lewis, C. Daigh, T.D. Hansen, D.A. Mann, J.A. Thomson, L.G. Griffith, R.D. Kamm, M.P. Schwartz, W.L. Murphy. Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Reviews and Reports. Accepted. internet_link.jpg

J-114.    J.W. Checco, D.F. Kreitler, N.C. Thomas, D.G. Belair, N.J. Rettko, W.L. Murphy, K.T. Forest, S.H. Gellman. Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold. Proceedings of the National Academy of Sciences, 2015; 112: 4552-4557.internet_link.jpg

J-113.    C.S. Chamberlain, J.S. Lee, E.M. Leiferman, N.X. Maassen, G.S. Baer, R. Vanderby, W.L. Murphy. Effects of BMP-12 releasing sutures on Achilles tendon healing. Tissue Engineering A, 2015; 21: 916-27.internet_link.jpg

J-112.    E. Saito, D. Suarez-Gonzalez, W.L. Murphy, S.J. Hollister. Biomineral coating increases in vivo bone formation by ex-vivo BMP-7 gene therapy in rapid prototyped poly (L-lactic acid) (PLLA) and poly (ε-caprolactone) (PCL) porous scaffolds. Advanced Healthcare Materials, 2015; 4: 621-632.internet_link.jpg


J-111.    D.G. Belair, N.N. Le, W.L. Murphy. Design of growth factor sequestering biomaterials. Chemical Communications, 2014; 50: 15651-15668.  internet_link.jpg

J-110.    X. Yu, W.L. Murphy. 3-D scaffold platform for optimized non-viral transfection of multipotent stem cells. Journal of Materials Chemistry B, 2014; 2: 8186-8193. internet_link.jpg

J-109.    S. Musah, P.J. Wrighton, Y. Zaltsman, X. Zhong, S. Zorn, M.B. Parlato, C. Hsiao, S.P. Palecek, Q. Chang, W.L. Murphy, L.L. Kiessling. Substratum-induced differentiation of human pluripotent stem cells reveals coactivator YAP as a potent regulator of neuronal specification. Proceedings of the National Academy of Sciences, 2014; 111: 13805-13810.internet_link.jpg

J-108.    Yu X, Takayama T, Goel SA, Shi X, Zhou Y, Kent KC, Murphy WL, Guo LW. A rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia. Journal of Controlled Release, 2014; 191: 47–53.  internet_link.jpg

J-107.    D. Suarez-Gonzalez, J.S. Lee, A. Diggs, Y. Lu, B. Nemke, M. Markel, S.J. Hollister, W.L. Murphy. Controlled multiple growth factor delivery from bone tissue engineering scaffolds. Tissue Engineering A, 2014;15:2077-87. internet_link.jpg

J-106.    D.G. Belair, A.S. Khalil, W.L. Murphy. Serum-dependence of affinity-mediatedVEGF release from biomimetic microspheres. Biomacromolecules, 2014;15:2038-48.internet_link.jpg

J-105.    X. Yu, A.S. Khalil, P.N. Dang, E. Alsberg, W.L. Murphy. Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery. Advanced Functional Materials, 2014;20:3082-93.internet_link.jpg

J-104.    C. Chamberlain, E. Leiferman, S. Brickson, G. Baer, W.L. Murphy, R. Vanderby. Interleukin-1 Receptor Antagonist Modulates Inflammation and Scarring after Ligament Injury. Connective Tissue Research, 2014;3:177-86.internet_link.jpg

J-103.     M. Parlato, Sarah Reichert, Neal Barney, W.L. Murphy. Poly(ethylene glycol) hydrogels with adaptable mechanical and degradation properties for biomedical applications. Macromolecular Bioscience, 2014; 14: 687-698.internet_link.jpg

J-102.    W.L. Murphy, T.C. McDevitt, A.J. Engler. Materials as stem cell regulators. Nature Materials, 2014; 13: 547-557.internet_link.jpg

J-101.     S.M. Kennedy, K.A. Beres, A.R. Hahn, S.J. Kamin, S.C. Hagness, J.H. Booske, W.L. Murphy. Cationic peptide exposure enhances pulsed-electric-field-mediated membrane disruption. PLoS One, 2014;9;e92528.internet_link.jpg

J-100.     W.F. Hynes, N.J. Doty, T.I. Zarembinski, M.P. Schwartz, M.W. Toepke, W.L. Murphy, S.K. Atzet, R. Clark, J.A. Melendez, N.C. Cady. Micropatterning of 3D microenvironments for living biosensor applications. Biosensors, 2014;4:28-44. internet_link.jpg

J-99.   T. Hansen, J.T. Koepsel,  N.N. Le, E.H. Nguyen, S. Zorn, M. Parlato, S.G. Loveland, M.P. Schwartz, W.L. Murphy. Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and non-tumorigenic human mesenchymal cell types. Biomaterials Science, 2014;5:745-56. internet_link.jpg

J-98.    A.S. Khalil, A.W. Xie, W.L. Murphy. Context clues: the importance of stem cell-material interactions. ACS Chemical Biology, 2014;9:45-56. internet_link.jpg

J-97.    E.H. Nguyen, M. Zanotelli, M.P. Schwartz, W.L. Murphy. Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. Biomaterials, 2014; 35: 2149-2161. internet_link.jpg

J-96.    Z. Hou, J. Zhang, M.P. Schwartz, R. Stewart, C.D. Page, W.L. Murphy, J.A. Thomson. A human pluripotent stem cell platform for assessing developmental neural toxicity screening. Stem Cell Research and Therapy, 2013;4.internet_link.jpg


J-95.    M.P. Schwartz*, S.P. Singh, J.Y. Lee, S.G. Loveland, J.T. Koepsel, R.E. Rogers, S.I. Montanez-Sauri, K.E. Sung, E.K. Sackmann, E.Y. Tokuda, L.M. Everhart, E.H. Nguyen, Y. Sharma, M.H. Zaman, D.J. Beebe, N.G. Ahn, W.L. Murphy*, K.S. Anseth*. A comparison between primary and transformed cells reveals a unique migration mode with mixed mesenchymal and amoeboid character. PLoS One, 2013; 8: e81689. internet_link.jpg

J-94.    K.E. Healy, T.C. McDevitt, W.L. Murphy, R.M. Nerem. Engineering the Emergence of Stem Cell Therapeutics. Science Translational Medicine, 2013;5:207.internet_link.jpg

J-93.    M. Parlato, A. Johnson, G.A. Hudalla, W.L. Murphy. Adaptable poly(ethylene glycol) microspheres capable of mixed mode degradation. Acta Biomaterialia, 2013; 9: 9270–9280.internet_link.jpg

J-92.    D. Belair, W.L. Murphy. Specific VEGF sequestering to biomaterials: influence of serum stability. Acta Biomaterialia 2013;9: 8823–8831.internet_link.jpg

J-91.    Nianli A. Zhang, James A. Molenda, William L. Murphy, Steven Mankoci, Xianfeng Zhou, Nita Sahai. Crystal structures of CaSiO3 polymorphs control growth and osteogenic differentiation of human mesenchymal stem cells on bioceramic surfaces, Biomaterials Science, 2013;1:1101-1110.internet_link.jpg

J-90.       C.S. Chamberlain, E.M. Leiferman, K.E. Frisch, S.L. Brickson, W.L. Murphy, G.S. Baer, R. Vanderby. Interleukin expression after injury and the effects of interleukin-1 receptor antagonist. PLoS One 2013;8:e71631.internet_link.jpg

J-89.       E. Saito, D. Suarez-Gonzalez, R. Rao, J. Stegemann, W.L. Murphy, S.J. Hollister. Use of micro-computed tomography to non-destructively characterize biomineral coatings on solid freeform fabricated poly (L-lactic acid) and poly (ε-caprolactone). Tissue Engineering C, 2013;19:507-517. internet_link.jpg

J-88.       H. Ardalani, A. Assadi, W.L. Murphy. Structure, function, and development of blood vessels: lessons for tissue engineering. In: Engineering in Translational Medicine. W. Cai, Editor. 

J-87.       M.B. Parlato, W.L. Murphy. Hydrogels for Autologous Stem Cell Recruitment. In: Hydrogels in Cell-Based Therapies. I. Hamley, C. Connon, Eds.

J-86.       M.W. Toepke, N.A. Impellitteri, J.M. Theisen, W.L. Murphy. Characterization of thiol-ene crosslinked PEG hydrogels. Macromolecular Materials and Engineering, 2013; 298: 699-703. internet_link.jpg

J-85.       S.H. Brounts, J.S. Lee, S. Weinberg, S.K. Lan Levengood, E.L. Smith, W.L. Murphy. High affinity binding of an engineered, modular peptide to bone tissue. Molecular Pharmaceutics, 2013;10:2086-90. internet_link.jpg

J-84.       S.Y. Choi, W.L. Murphy. A screening approach reveals the influence of mineral coating morphology on human mesenchymal stem cell differentiation. Biotechnology Journal, 2013; 8: 496-501. (Featured in “In this issue” section of Biotechnology Journal). internet_link.jpg

J-83.       S.Y. Choi, X. Yu, L. Jongpaiboonkit, S.J. Hollister, W.L. Murphy. Inorganic coatings for optimized non-viral transfection of stem cells. Scientific Reports, 2013; 3: 1567. internet_link.jpg

J-82.       J.S. Lee, W.L. Murphy. Functionalizing calcium phosphate biomaterials with antibacterial silver particles. Advanced Materials, 2013; 25: 1173–1179. internet_link.jpg

J-81.       S.K. Schmitt, W.L. Murphy, P. Gopalan. Crosslinked PEG mats for peptide immobilization and stem cell adhesion. Journal of Materials Chemistry B 2013, 1, 1349-1360. internet_link.jpg


J-80.    T. Franklin-Ford, J.S. Lee, D. Suarez-Gonzalez, W.L. Murphy. Biomimetic Hydroxyapatite Materials for Therapeutic Delivery. CRC Handbook of Hydroxyapatite for Biomedical Applications. S. Zhang, Ed., 2012. internet_link.jpg

J-79.    M.J. Wilson, Y. Jiang, B. Yanez-Soto, S.J. Liliensiek, W.L. Murphy, P.F. Nealey. Arrays of topographically and peptide-functionalized hydrogels for analysis of biomimetic extracellular matrix properties. Journal of Vacuum Science and Technology B, 2012; 30: 06F903-1-06F903-7. internet_link.jpg

J-78.    J.A. Burdick, W.L. Murphy. Moving from static to dynamic complexity in hydrogel design. Nature Communications, 2012; 3: 1269. internet_link.jpg

J-77.    T. Franklin-Ford Ellis, N. Shah, E. Leiferman, C. Chamberlain, A. Raval, R. Vanderby, W.L. Murphy. Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles. Macromolecular Bioscience, 2012; 12: 1615–1621. internet_link.jpg

J-76.    Y. Lu, J.S. Lee, B. Nemke, B.K. Graf, K. Royalty, R. Illgen III, R. Vanderby Jr., M.D. Markel, W.L. Murphy. Coating with a modular bone morphogenetic peptide promotes healing of a bone-implant gap in an ovine model. PLoS One, 2012; 7: e50378. internet_link.jpg

J-75.    S.Y. Choi, W.L. Murphy. The effect of mineral coating morphology on mesenchymal stem cell attachment and expansion. Journal of Materials Chemistry, 2012; 22: 25288-25295. internet_link.jpg

J-74.    J.T. Koepsel, S.G. Loveland, M.P. Schwartz, S. Zorn, D.G. Belair, N.N. Le, W.L. Murphy. A chemically-defined screening platform reveals behavioral similarities of primary human mesenchymal stem cells and endothelial cells. Integrative Biology, 2012; 4: 1508–1521. internet_link.jpg

J-73.    J.T. Koepsel, P.T. Brown, S.G. Loveland, W.J. Li, W.L. Murphy. Combinatorial screening of chemically-defined human mesenchymal stem cell culture substrates. Journal of Materials Chemistry, 2012; 22: 19474-19481. internet_link.jpg

J-72.       J.T. Koepsel, W.L. Murphy. Patterned SAM substrates: Efficient, chemically-defined tools for cell biology, ChemBioChem, 2012; 13:1717-1724. internet_link.jpg

J-71.       J.T. Koepsel, E.H. Nguyen, W.L. Murphy. Differential effects of a soluble or immobilized VEGFR-binding peptide. Integrative Biology, 2012; 4: 914-924. internet_link.jpg

J-70.       M.W. Toepke, N.A. Impellitteri, S.K. Lan Levengood, D.S. Boeldt, I.M. Bird, W.L. Murphy. Regulating specific growth factor signaling using immobilized branched ligands. Advanced Healthcare Materials, 2012; 1: 457–460. internet_link.jpg

J-69.       H.S. Haase, K.J. Peterson-Kaufman, S.K. Lan Levengood, J.W. Checco, W.L. Murphy*. S.H. Gellman*. Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling. Journal of the American Chemical Society, 2012; 134: 7652-7655. (Featured in Virtual Issue on “Peptide Chemistry” based on scientific quality and broad appeal). internet_link.jpg

J-68.       W.J. King, N. Kouris, S.Y. Choi, B.M. Ogle, W.L. Murphy. Environmental parameters influence non-viral transfection of human mesenchymal stem cells for tissue engineering applications. Cell and Tissue Research, 2012; 347: 689-699. internet_link.jpg

J-67.       N.A. Impellitteri, M.W. Toepke, S.K. Lan Levengood, W.L. Murphy. Specific VEGF sequestering and release using peptide-functionalized hydrogel microspheres. Biomaterials, 2012; 33: 3475-3484. internet_link.jpg

J-66.       D. Suarez-Gonzalez, J.S. Lee, S.K. Lan Levengood, R. Vanderby Jr., W.L. Murphy. Mineral coatings modulate β-TCP stability and enable growth factor binding and release. Acta Biomaterialia, 2012; 8: 1117-1124. internet_link.jpg

J-65.       M.J. Wilson, S.J. Liliensiek, C.J. Murphy, W.L. Murphy, P.F. Nealey. Hydrogels with well-defined peptide-hydrogel spacing and concentration: impact on epithelial cell behavior. Soft Matter, 2012; 8: 390-398. internet_link.jpg

J-64.       D. Suarez-Gonzalez, K. Barnhart, F. Migneco, L.R. Eichacker, C. Flanagan, S.J. Hollister, W.L. Murphy. Controllable mineral coatings on PCL scaffolds as carriers for growth factor release. Biomaterials, 2012; 33: 713-21. internet_link.jpg


J-63.    G.A. Hudalla, J.T. Koepsel, W.L. Murphy. Surfaces that sequester serum-borne heparin amplify growth factor activity. Advanced Materials, 2011; 23: 5415-5418. internet_link.jpg

J-62.    S.J. Hollister, W.L. Murphy. Scaffold translation: barriers between concept and clinic. Tissue Engineering B, 2011; 17: 459-474. internet_link.jpg

J-61.    J.S. Lee, D. Suarez-Gonzalez, W.L. Murphy. Mineral Coatings for Temporally Controlled Delivery of Multiple Proteins. Advanced Materials, 2011; 23: 4279–4284. (Featured as Frontispiece in Advanced Materials). internet_link.jpg

J-60.    Y. Lu, J.S. Lee, B. Nemke, G. Baer, B. Graf, W.L. Murphy*, M.D. Markel. Histologic evaluation of suture material loaded with basic fibroblast growth factor (bFGF) on acute rotator cuff repair in an ovine model. Current Orthopaedic Practice, 2011; 22: 425-431.  (*Corresponding Author). internet_link.jpg

J-59.    G.A. Hudalla, N. Kouris, J.T. Koepsel, B.M. Ogle, W.L. Murphy. Harnessing endogenous growth factor activity modulates stem cell behavior. Integrative Biology, 2011; 3: 832–842. internet_link.jpg

J-58.       G.A. Hudalla, W.L. Murphy. Chemically well-defined self-assembled monolayers for cell culture: Toward mimicking the natural ECM. Soft Matter, 2011; 7: 9561 - 9571. (Featured as “Hot Article” in Soft Matter). internet_link.jpg

J-57.       G.A. Hudalla, W.L. Murphy. Biomaterials that Regulate Growth Factor Activity via Bioinspired Interactions. Advanced Functional Materials, 2011; 21: 1754-1768. (Featured in as “very important and very urgent”). internet_link.jpg

J-56.       W.L. Murphy. Emerging area: Biomaterials that mimic and exploit protein motion. Soft Matter, 2011; 7: 3679-3688. (Featured as “Hot Article” in Soft Matter). internet_link.jpg

J-55.       E. Nguyen, M.P. Schwartz, W.L. Murphy. Biomimetic approaches to control soluble protein concentration gradients in biomaterials. Macromolecular Bioscience, 2011; 11: 483-492. internet_link.jpg

J-54.       W.J. King, W.L. Murphy. Bioinspired conformational changes: an adaptable mechanism for bio-responsive drug delivery. Polymer Chemistry. 2011; 2: 476-491. internet_link.jpg

J-53.       W.J. King, M. Toepke, W.L. Murphy. Facile formation of dynamic hydrogel microspheres for triggered growth factor delivery. Acta Biomaterialia, 2011; 7: 975-985. internet_link.jpg

J-52.       W.J. King, M. Toepke, W.L. Murphy. A general route for the synthesis of functional, protein-based hydrogel microspheres using tailored protein charge. Chemical Communications, 2011; 47: 526-528. (Featured in “Emerging Investigators” issue). internet_link.jpg

J-51.       M. Toepke, W.L. Murphy. Dynamic Hydrogels. In: Comprehensive Biomaterials, K. Healy, P. Ducheyne, J. Kirkpatrick, D. Hutmacher, Eds., 2011. internet_link.jpg

J-50.       J.T. Koepsel, W.L. Murphy. Spatial localization of growth factors to regulate stem cell fate. In: Stem Cells and Revascularization in Therapies, A. Putnam, H.J. Kong, L. Schook, Eds., 2011. internet_link.jpg


J-49.    J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. A modular, hydroxyapatite-binding version of vascular endothelial growth factor. Advanced Materials, 2010; 22: 5494-5498. (Featured on Cover; Featured in as “very important and very urgent”). internet_link.jpg

J-48.       J.S. Lee, Y. Lu, G.S. Baer, M.D. Markel, W.L. Murphy. Controllable protein delivery from coated surgical sutures. Journal of Materials Chemistry, 2010, 20, 8894-8903. internet_link.jpg

J-47.       D. Suarez-Gonzalez, K. Barnhart, E. Saito, R. Vanderby, Jr., Scott J. Hollister, W.L. Murphy. Controlled nucleation of hydroxyapatite on alginate scaffolds for stem cell-based bone tissue engineering, Journal of Biomedical Materials Research A, 2010; 95: 222-34. internet_link.jpg

J-46.       N. Zhang, J. Molenda, W.L. Murphy, J. Fournelle, N. Sahai. Effects of pseudowollastonite (CaSiO3) bioceramic on in vitroactivity of human mesenchymal stem cells. Biomaterials, 2010; 31: 7653-7665. internet_link.jpg

J-45.       S.Y. Choi, W.L. Murphy. Sustained plasmid DNA release from dissolving mineral coatings. Acta Biomaterialia, 2010; 6: 3426-3435. internet_link.jpg

J-44.       S.K. Lan-Levengood, W.L. Murphy. Biomaterials for high-throughput stem cell culture. Current Stem Cell Research and Therapy. 2010; 5: 261-267. internet_link.jpg

J-43.       W.J. King, N.J. Pytel, K. Ng, W.L. Murphy. Triggered drug release from dynamic microspheres via a protein conformational change. Macromolecular Bioscience, 2010; 10: 580-584 (Cover Article, featured in “Best of Macromolecular Journals 2011”). internet_link.jpg

J-42.       G.A. Hudalla, W.L. Murphy. Immobilization of peptides with distinct biological activities onto stem cell culture substrates using orthogonal chemistries. Langmuir, 2010; 26: 6449-6456. internet_link.jpg

J-41.       W.J. King, L. Jongpaiboonkit, W.L. Murphy. Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreading, Journal of Biomedical Materials Research A, 2010; 93:1110-1123. internet_link.jpg

J-40.       J.S. Lee, J.S. Lee, W.L. Murphy. Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces, Acta Biomaterialia, 2010; 6: 21-28. internet_link.jpg


J-39.    Z. Sui, W.L. Murphy. Nanoscale Mechanisms for Assembly of Biomaterials. In: Nanoscience and its applications to Biomedicine, D. Shi, Ed., 2009. internet_link.jpg

J-38.    Y. Lu, M.D. Markel, B. Nemke, J.S. Lee, B.K. Graf, W.L. Murphy. Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model, Arthroscopy, 2009; 20: 1427-34. internet_link.jpg

J-37.    J.T. Koepsel, W.L. Murphy. Patterning discrete stem cell culture environments via localized SAM replacement, Langmuir, 2009; 25: 12825-34. internet_link.jpg

J-36.       L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Growth of Hydroxyapatite Coatings on Biodegradable Polymer Microspheres, ACS Applied Materials and Interfaces, 2009; 1: 1504-1511. internet_link.jpg

J-35.       J.S. Lee, J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation, Angewandte Chemie Int. Ed., 2009; 48: 6266-6270. internet_link.jpg

J-34.       K.J. Regehr, M. Domenech, J.T. Koepsel, K.C. Carver, S.J. Ellison-Zelski, W.L. Murphy, L.A. Schuler, E.T. Alarid, D.J. Beebe. Biological implications of polydimethylsiloxane-based microfluidic cell culture, Lab on a Chip, 2009; 9: 2132-2139. internet_link.jpg

J-33.       W.J. King, J.Shaikh Mohammed, W.L. Murphy. Modulating growth factor release from hydrogels via a protein conformational change. Soft Matter, 2009; 5: 2399-2406. internet_link.jpg

J-32.       J. Shaikh Mohammed, W.L. Murphy. Bioinspired design of dynamic materials. Advanced Materials, 2009;21:2361-2374. internet_link.jpg

J-31.       G.A. Hudalla, W.L. Murphy. Using "click" chemistry to prepare SAM substrates to study stem cell adhesion, Langmuir, 2009;25:5737-5746. internet_link.jpg

J-30.       W.L. Murphy, J.H. Collier. Self-assembling biomaterials, Acta Biomaterialia, 2009;5:803-804. internet_link.jpg

J-29.       L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release, Advanced Materials, 2009;21:1960–1963. internet_link.jpg

J-28.       L. Jongpaiboonkit, W.J. King, W.L. Murphy. Screening for 3-D environments that support human mesenchymal stem cell viability using hydrogel arrays, Tissue Engineering A, 2009;15:343-353. internet_link.jpg

C-8.    W.L. Murphy. Temporal and spatial control over soluble protein signaling for musculoskeletal tissue engineering, Proceedings of the IEEE-EMBS conference, 2009. internet_link.jpg


J-27.       D. Suarez-Gonzalez, W.L. Murphy. Bio-Inspired Growth of Mineralized Tissues. In: Biomineralization: from Nature to Application. A. Sigel, H. Sigel, R.K.O. Sigel, Eds., 2008. internet_link.jpg

J-26.       J.W. Warrick, W.L. Murphy, D.J. Beebe. Screening the cellular microenvironment: A role for microfluidics. IEEE Review of Biomedical Engineering, 2008; 1: 75-94. internet_link.jpg

J-25.       B.J. Peret, W.L. Murphy. Controllable soluble protein concentration gradients in hydrogel networks, Advanced Functional Materials, 2008; 18: 3410-3417.internet_link.jpg

J-24.       S. Choi, W.L. Murphy. Multifunctional mixed SAMs that promote both cell adhesion and non-covalent DNA immobilization, Langmuir, 2008; 24:6873-6880. internet_link.jpg

J-23.       Z. Sui, W.J. King, W.L. Murphy. Protein-based hydrogels with tunable dynamic responses, Advanced Functional Materials, 2008;18:1824-1831. internet_link.jpg

J-22.       L. Jongpaiboonkit, W.J. King, G.E. Lyons, A. Paguirigan, J. Warrick, D.J. Beebe, W.L. Murphy, An adaptable hydrogel array format for 3-dimensional cell culture and analysis, Biomaterials, 2008;29:3346-3356. internet_link.jpg

J-21.       G. Hudalla, T.S. Eng, W.L. Murphy. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks, Biomacromolecules, 2008; 9:842-849. internet_link.jpg

C-7.    G.A. Hudalla, W.L. Murphy. Using non-covalent interactions to modulate local soluble signaling. PMSE Preprints, American Chemical Society, Spring, 2008. 


J-20.       Z. Sui, W.J. King, W.L. Murphy. Dynamic materials based on a protein conformational change. Advanced Materials, 2007;19:3377-3380. (Featured in Advances in Advance section, Adv Mat, 10/2007) internet_link.jpg

J-19.       K.S. Masters, W.L. Murphy. Tissue Engineering. In: Encyclopedia of Medical Devices and Instrumentation, J.G. Webster, Ed., 2007. internet_link.jpg

J-18.       W.L. Murphy, K. Grorud, R. Vanderby. Healing of Bone and Connective Tissues. In: Encyclopedia of Biomaterials and Biomedical Engineering, G. Wnek, G. Bowlin, Eds., 2007. internet_link.jpg

J-17.       W.L. Murphy, W.S. Dillmore, J. Modica, M. Mrksich. Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion. Angewandte Chemie Int. Ed., 2007;46:3066-3069. (Featured in Editor’s Choice section, Science, 05/2007) internet_link.jpg

J-16.       Jason L. Wyman, Seda Kizilel, Ryan Skarbek, Xiangyang Zhao, Matthew Connors, William S. Dillmore, William L. Murphy,  Milan Mrksich, Sidney R. Nagel, Marc R. Garfinkel. Immunoisolating Pancreatic Islets by Encapsulation with Selective Withdrawal. Small, 2007;3:683-690. internet_link.jpg

C-6.    G.A. Hudalla, W.L. Murphy. Non-covalent assembly of peptide-growth factor complexes to spatially control cell activity. PMSE Preprints, American Chemical Society, Spring, 2007. internet_link.jpg

C-5.    Z. Sui, W.J. King, W.L. Murphy. Influence of network parameters on the properties of dynamic, protein-based hydrogels. PMSE Preprints, American Chemical Society, Fall, 2007. internet_link.jpg


J-15.       W.L. Murphy, S. Hsiong, T.P. Richardson, C.A. Simmons, D.J. Mooney. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials 2005;26:303-310. internet_link.jpg


J-14.       W.L. Murphy, K.O. Mercurius, S. Koide, M. Mrksich. Substrates for Cell Adhesion Prepared via Active Site-Directed Immobilization of a Protein Domain. Langmuir 2004;20:1026-1030. internet_link.jpg

J-13.       W.L. Murphy, C.A. Simmons, D. Kaigler, D.J. Mooney. Bone Regeneration via a Mineral Substrate and Induced Angiogenesis. Journal of Dental Research 2004;83:204-210. (Awarded the 2005 IADR/AADR William Gies Award for best Bioengineering/Biomaterials paper in JDR in 2004). internet_link.jpg


J-12.       T.P. Richardson, W.L. Murphy, D.J. Mooney. Selective adipose tissue ablation by localized, sustained drug delivery. Plastic and Reconstructive Surgery 2003;112:162-170. internet_link.jpg


J-11.       W.L. Murphy, D.J. Mooney. Tissue Engineering in Orthodontics. Chapter 22 In: Essentials for Orthodontic Practice. J. Avery, Ed, 2002.

J-10.       W.L. Murphy, D.J. Mooney. Bioinspired growth of crystalline carbonate apatite on biodegradable polymer substrata. Journal of the American Chemical Society 2002;124:1910-1917. internet_link.jpg

J-9.       W.L. Murphy, R.G. Dennis, J.L. Kileny, D.J. Mooney. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Engineering 2002;8:43-52. internet_link.jpg

J-8.       W.L. Murphy, D.J. Mooney. Molecular-scale biomimicry. Nature Biotechnology 2002;20:30. internet_link.jpg

C-4.    W.L. Murphy, C.A. Simmons, D.J. Mooney. A combination approach to engineering bone regeneration: biomineral presentation and induced angiogenesis. Proceedings of the EMBS-BMES conference, 2002, Vol. 3, p. 886-887, 2002. internet_link.jpg


J-7.       T.P. Richardson, W.L. Murphy, D.J. Mooney. Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy. Critical Reviews in Eukaryotic Gene Expression 2001;11:47-58. internet_link.jpg

C-3.    W.L. Murphy, K.A. Gilhool, D.J. Mooney. Biomineralization via bioinspired variation in polymer surface chemistry. PMSE Preprints, American Chemical Society, Fall, 2001.


J-6.       W.L. Murphy and P.B. Messersmith. Thermally Triggered Mineralization of Calcium Phosphate Using Phosphate-Loaded Liposomes. In: Chemistry and Biology of Mineralized Tissues, M. Goldberg, A. Boskey, C. Robinson, eds., AAOS, Rosemont, IL, 2000:393-397. 

J-5.       W.L. Murphy, M.C. Peters, D.H. Kohn, D.J. Mooney. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials 2000;24:2521-2527. internet_link.jpg

J-4.       W.L. Murphy, D.H. Kohn, D.J. Mooney. Growth of continuous bone-like mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. Journal of Biomedical Materials Research 2000;50:50-58 (Cover Article). internet_link.jpg

J-3.       W.L. Murphy, P.B. Messersmith. Compartmental control of mineral formation: adaptation of a biomineralization strategy for biomedical use. Polyhedron 2000;19:357-363. internet_link.jpg


J-2.       W.L. Murphy, D.J. Mooney. Controlled delivery of inductive proteins, plasmid DNA, and cells from tissue engineering matrices. Journal of Periodontal Research 1999;34:413-419. internet_link.jpg

J-1.       W.L. Murphy, G.C. Spalding. Range of interactions: An experiment in atomic and magnetic force microscopy. American Journal of Physics 1999;67:905-909. internet_link.jpg

C-2.    W.L. Murphy, K.A. Gilhool, D.H. Kohn, D.J. Mooney. Effects of growth factor presence on mineralization of porous poly(lactide-co-glycolide) scaffolds in vitro. In: Mineralization in Natural and Synthetic Biomaterials, Materials Research Society. P. Li, P. Calvert, R.J. Levy, T. Kokubo, C.R. Schneid, Eds., 1999. internet_link.jpg

C-1.    G.C. Spalding, W.L. Murphy, T.M. Davidsmeier, J.E. Elenewski. Faceting of the (100) face of single-crystal SrTiO3 during wet chemical etching. In: Substrate Engineering: Paving the Way to Epitaxy, D.P. Norton, D.G. Schlom, N. Newman, D.H. Matthies, Eds., Materials Research Society, 1999.