Tech Transfer

The Murphy Group is actively pursuing technology transfer efforts in conjunction with the Wisconsin Alumni Research Foundation (WARF). For details on these efforts please contact Dr. Murphy (wlmurphy@wisc.edu) or Jeanine Burmania (jeanine@warf.org) at WARF.

Patents

IP-48.  Mineral-coated microparticles for sustained delivery of steroids  A.E. Clements, W.L. Murphy, B. Kurokawa. Patent Application filed, 2018.

IP-47.  Chemically defined differentiation protocol for pericyte differentiation from pluripotent stem cells   W.T. Daly, C. Soref, W.L. Murphy. Patent Application filed, 2018.

IP-46. Delivery of biologics via mineral nanocrystals for regenerative medicine applications.    G. Fontana, A.S. Khalil, J.S. Lee, W.L. Murphy. Patent Application filed, 2018.

IP-45.  Structured nanocoatings for the stabilization of pluripotent stem cell media components   W.L. Murphy, A.S. Khalil, A.W. Xie, Hunter Johnson. Patent Application filed, 2018.

IP-44.  Osteostimulatory mineral coatings that reduce bacterial adhesion.   L. Jongpaiboonkit, W.L. Murphy. Patent Application filed, 2017.

IP-43.  Mineral-coated microparticles for gene delivery in chronic wound therapy   A.S. Khalil, X. Yu, W.L. Murphy.  Patent Application filed, 2017.

IP-42.  Mineral-coated microparticles for the co-delivery of anti-inflammatory molecules with nucleic acids to improve gene delivery outcomes  A.S. Khalil, X. Yu, W.L. Murphy. Patent Application filed, 2017.

IP-41.  Mineral coated microparticles for sustained delivery of biologically active molecules   A. Clements, C. Chamberlain, R. Vanderby Jr., W.L. Murphy. Patent Application filed, 2017.

IP-40.  Visible light polymerization of PEG hydrogels  A.S. Khalil, C. Lebakken, W.L. Murphy. Patent Application filed, 2017.

IP-39.  Functionalization of plant tissues for human cell expansion  W.L. Murphy, G. Fontana. Patent Application filed, 2017.

IP-38.  Decellularization of plant tissues.  J. Gershlak, G. Gaudette, P. Weathers, T. Dominko, M. Rolle, S. Hernandez, W.L. Murphy, C. Cramer, Fabricio Medina-Bolivar. Patent Application filed, 2016.

IP-37.  TGF-β1-binding peptides and hydrogel microspheres containing the peptides for growth factor regulation in blood products.  D.G. Belair, N.N. Le, A. Kellner, W.L. Murphy. Patent Application filed, 2016.

IP-36.  Hydrogel spheres containing peptide ligands for growth factor regulation.   D.G. Belair, N.N. Le, W.L. Murphy. Patent Application filed, 2016.

IP-35.  Development of HEPpep and heparin coatings for MSC spheroid microtissue assembly.  J. Lei, W.L. Murphy, J.S. Temenoff.  Patent Application filed, 2016.

IP-34. Fluoride-doped inorganic coatings for controlled delivery of DNA, RNA, and protein-RNA hybrids.  A.S. Khalil, X. Yu, K. Saha, J. Carlson-Stevermer, B. Steyer, W.L. Murphy. Patent Application, Filed 2015.

IP-33. Mineral-coated Scaffolds L. Jongpaiboonkit, W.L. Murphy. Patent Application, Filed 2015.

IP-32. Coating scaffolds L. Jongpaiboonkit, W.L. Murphy. Patent Application, Filed 2015.

IP-31. Hydrogel arrays for cell expansion and differentiation. N.N. Le, M. Parlato, J.A. Molenda, W.L. Murphy.  U.S. Patent Application, Filed 2015.

IP-30.  Synthetic hydrogel compositions that promote endothelial cell tubulogenesis.  W.L. Murphy, E. Nguyen, M. Schwartz, H. Ardalani, M. Zanotelli, M. Parlato, D. Belair, W. Daly, N.N. Le. U.S. Patent Application Filed, 2015.

IP-29.  Azlactone based thermally crosslinkable polymer coating for controlling cell behavior  S.K. Schmitt,  P. Gopalan, W.L. Murphy. U.S. Patent Application, Filed 2015.

IP-28.  Perivascular delivery system and method.  L. Guo, X. Yu, W.L. Murphy, C. Kent. U.S. Patent Application, Filed 2014.

IP-27.  Human pluripotent stem cell-based models for predictive developmental neural toxicity  Z. Hou, M.P. Schwartz, W.L. Murphy, J.A. Thomson. U.S. Patent Application, Filed 2014.

IP-26.  Chemically labile peptide-presenting surfaces for cellular self-assembly.  A.W. Xie, W.L. Murphy.  U.S. Patent Application, Continuation in part, Filed 2014.

IP-25.  Custom coatings on orthopedic implants.  L. Jongpaiboonkit, W.L. Murphy.  U.S. Patent Application Filed, 2014.

IP-24.  Photopolymerization patterning for formation of covalently-immobilized hydrogel arrays in multi-well plates.   N.N. Le, W.L. Murphy.  U.S. Patent Application Filed, 2014.

IP-23.  Novel method for forming hydrogel arrays using surfaces with differential wettability  N.N. Le, S. Zorn, M.P. Schwartz, E.H. Nguyen, W.L. Murphy. U.S. Patent Application Filed, 2014.

IP-22.  Methods of decorating hydroxyapatite biomaterials with modular, biologically active molecules  W.L. Murphy, J.S. Lee, J.S. Lee, M. Markel, B. Graf. U.S. Patent Application Filed, 2013.

IP-21.  Enhanced throughput mineral coatings for optimization of stem cell behavior  W.L. Murphy, S. Choi, X. Yu.  Patent Application filed, 2013.

IP-20.  Substrates for generation of controlled human pluripotent stem cell colony size  W.L. Murphy, S. Lan Levengood, J.T. Koepsel, S. Zorn, T. Keenan.  Patent Application filed, 2012.

IP-19.  Modular, bioactive peptide binds to bone and improves bone graft osteoinductivity   W.L. Murphy, S. Lan Levengood, S. Brounts. Patent Application filed, 2012.

IP-18. Modular tissue scaffolds   S.J. Hollister, S.J. Feinberg, W.L. Murphy, L. Jongpaiboonkit, J.R. Adox, F. Migneco. Patent Application Filed, 2012.

IP-17.  Chemically-defined arrays for screening cell-substrate interactions.  W.L. Murphy, J.T. Koepsel. Patent Application Filed, 2012.

IP-16.  Medical device coatings that bind and deliver blood components.   W.L. Murphy, R. Vanderby, G. Baer, B. Graf, J.S. Lee, C. Chamberlain. Patent Application Filed, 2011.

IP-15.  Degradable cage coated with mineral layers for spinal interbody fusion.  C.Y. Lin, F. LaMarca, W.L. Murphy, S.J. Hollister. Continuation in Part Application Filed, 2011.

IP-14. Tissue regeneration system   J.S. Lee, D. Suarez-Gonzalez, M. Markel, Y. Lu, B. Graf, W.L. Murphy. U.S. Patent Application Filed (serial #12/796743), 2010.

IP-13. Biologically active sutures for regenerative medicine J.S. Lee, M. Markel, B. Graf, G. Baer, Y. Lu, W.L. Murphy. U.S. Patent Application Filed (serial #12/507635), 2009.

IP-12. Proteoglycan-binding peptides that modulate stem cell behavior.  G. Hudalla, W.L. Murphy. Patent Application Filed (serial #61/326945), 2009.

IP-11. Decorating hydroxyapatite biomaterials with modular, biologically active molecules.  W.L. Murphy, J.S. Lee, J.S. Lee, M. Markel, B. Graf. U.S. Patent Application Filed (serial #12/628666), 2009.

IP-10. Mineral-coated microspheres L. Jongpaiboonkit, W.L. Murphy. U.S. Patent Application Filed, 2008.

IP-9. Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery W.L. Murphy, J.S. Lee, M. Markel, B. Graf.  U.S. Patent Application Filed (serial #12/145672), 2008.

IP-8. Degradable cage coated with mineral layers for spinal interbody fusion. C.Y. Lin, F. LaMarca, W.L. Murphy, S.J. Hollister. U.S. Patent Application Filed (serial #11/927322), 2006.

IP-7. Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration C.Y. Lin, F. LaMarca, S. Feinberg, W.L. Murphy, J. Adox, S.J. Hollister. U.S. Patent US 8,275,594 B2.

IP-6. Multilayer tissue regeneration system. W.L. Murphy.  U.S. Patent Application 20080095817 (serial #11/583231), 2006.

IP-5. Method and system for delivery of a nucleic acid into a target cell. W.L. Murphy, S. Choi. U.S. Patent Application 20070092906 (serial #11/583223), 2006.

IP-4. Spatial control of signal transduction. W.L. Murphy, G. Hudalla. U.S. Patent Application 60675225 (serial #11/412450), 2006.

IP-3. Tissue engineering scaffolds W.L. Murphy, R.G. Dennis, D.J. Mooney. U.S. Patent 7,575,759.

IP-2. Mineralization and biological modification of biomaterial surfaces W.L. Murphy, M.C. Peters, D.J. Mooney.  U.S. Patent 6,767,928.

IP-1. Mineral and cellular patterning on biomaterial surfaces  W.L. Murphy, M.T. Dearing, G.C. Spalding, D.J. Mooney, D.H. Kohn. U.S. Patent 6,541,022.