3D brain-on-a-chip helps predict drug neurotoxicity

NIH-funded engineered brain tissue identifies toxins correctly 9 out of 10 times

To help test the toxicity of new drugs, NIBIB researchers have engineered a 3D brain organoid—a miniature organ structure that attempts to mimic the function of the organ but does not develop fully.  In a paper published in PNAS, the teams from the Morgridge Institute for Research and the University of Wisconsin-Madison describe how they developed a chip with neural tissue that possess many traits of brain tissue, including neurons, support cells, vascular structure and immune cells. Read Full Article Here and Here