Department Affiliation:
Department of Orthopedics and Rehabilitation, School of Medicine and Public Health
Education Background:
Ph.D. Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI
B.S. Molecular and Cellular Biology, University of Puget Sound, Tacoma, WA
Research Description:
Developing targeted gene therapies for inherited neurological disorders.
Publications:
- Smith FM, Schrope JH, Bennin DA, Horn A, Wagner AS, Hou Y, Stevens JJ, Giese MA, Dinh HQ, and Anna Huttenlocher. The paracrine factor Myeloid Derived Growth Factor regulates the inflammatory fate and motility of human induced pluripotent stem cell-derived neutrophils. J Immunol. 2026.
- Datta R, Miskolci V, Gallego-Lopez GM, Britt E, Gillette A, Kralovec A, Giese MA, Gian T, Fan J, Huttenlocher A, and Melissa C. Skala. Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophil activation across biological systems. Front Immunol.
- Wagner AS, Smith FM, Bennin DA, Votava JA, Data R, Giese MA, Zhao W, Skala MC, Fan J, Keller NP, and Anna Huttenlocher. GATA-1 deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity mediated by integrin CD18. PLOS Pathogens.
- Ramakrishnan G, Miskolci V, Hunter M, Giese MA, Muench D, Hou Y, Eliceiri KW, Lasarev MR, White R, and Anna Huttenlocher. Real time imaging reveals a role for macrophage protrusive motility in melanoma invasion. J Cell Bio.
- Giese MA, Ramakrishnan G, Dovan JX, Laura Steenberge, Sauer JD and Anna Huttenlocher. Bacterial lipolysis of aureus ligands promotes melanoma invasion. Disease Mod Mech. 2024.
- Giese MA, Bennin D, Schoen T, Peterson AN, Schrope JH, Brand J, Jung HS, Keller NP, Beebe DJ, Dinh HQ, Slukvin I, and A Huttenlocher. PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function. 2024.
- Schoen TJ, Calise DG, Bok JW, Giese MA, Nwagwu CD, Zarnowski R, Andes D, Huttenlocher A, Keller NP. Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection. PLoS Pathogens.
- Korte B*, Giese MA*, Ramakrishnan G, Ma Stella, Bennin D, Rindy J, Dewey C, and A Huttenlocher. Cell Type Specific Transcriptome Profiling Reveals a Role for Thioredoxin during Tumor Initiation. Frontiers in Immunology. (*Authors contributed equally)
- Britt E, Lika J, Giese MA, Schoen T, Seim G, Huang Z, Lee P, Huttenlocher A, and J Fan. Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils. Nature Metabolism.
- Hind LE, Giese MA, Schoen T, Beebe D, Keller N, and A Huttenlocher. Innate Immune Cell Paracrine Signaling Drives the Neutrophil Response to Aspergillus fumigatus in an Infection-on-a-Chip Model. Cellular and Molecular Bioengineering, 2021.
- Giese MA *, Hind LE*, and A Huttenlocher. Neutrophil Plasticity in the Tumor Microenvironment. Blood, 2019. (*Authors contributed equally)
- Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, and HP Kiem. Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice. Molecular Therapy, 2018.
- Radtke S, Adair JA, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, and HP Kiem. A Distinct Hematopoietic Stem/Progenitor Cell Population for Rapid Multilineage Engraftment. Science Translational Medicine, 2017.
Patents:
- Slukvin I, Huttenlocher A, Giese MA, Jung HS, Bennin DA: Protein Tyrosine Phosphatase 1B Inhibited Neutrophils, 2022. (US No. 18/296,895; PCT/US2023/065475; European No. 23785642.2)
Awards and honors:
- NIH Microbes in Health and Disease T32 Fellowship (2020-2022)
- CMB Graduate Program Travel Award (2019 & 2022)
- American Association of Immunologists Young Investigator Award (2021)
- NSF GRFP Honorable Mention (2019)